New treatment for safe skin cell rejuvenation

Turn Biotechnologies has released preliminary data that show its therapies rejuvenate skin cells more effectively and safely than existing treatments. The company is known for developing novel mRNA medicines to cure untreatable, age-related conditions,

The company's ERA™ (Epigenetic Reprogramming of Aging) treatment, precisely transported using Turn Bio's proprietary eTurna™ lipid-based delivery platform, reversed the hallmarks of aging in human skin – something never before achieved. The treatment simultaneously increased fibroblasts and collagen VII to restore the production of collagen and elastin, and reduced inflammation markers, oxidative stress, senescence, and MMPs, proteins responsible for skin degradation versus those untreated.

Preclinical data were presented to dermatologists and industry KOLs attending four global conferences in the past five weeks: Global Aesthetics Conference in Miami; Cosmetic Surgery Forum in Nashville, Tennessee; Beauty Through Science in New York City, and The Longevity Summit in San Francisco, California.

"The data suggest we may be close to redefining the care dermatologists can provide their patients," said Jill Waibel, a board-certified dermatologist and respected regenerative medicine researcher who presented findings at the Global Aesthetics Conference. "The potential to improve the quality of patients' skin – its elasticity and its ability to heal – could change the future of regenerative medicine."

Collagen VII expression (in red) is seen at the dermal-epidermal junction after treatment with Turn Biotechnologies' ERA(tm). Cell nuclei stained with DAPI (blue).

Hema Sundaram, a board-certified dermatologist and noted researcher in regenerative medicine and cell science, presented the data at Cosmetic Surgery Forum.

"This early research suggests that ERA could significantly improve the balance between key biomarkers of cell aging and cell youthfulness," she said. "From an evidence-based perspective, this carries more weight as a rejuvenation strategy than efforts to improve a single biomarker. Research of this type may open the door to a new paradigm of dermatologic care."

Data were also presented during sessions of the Beauty Through Science conference and the Longevity Summit.

"We believe this promises to be a game-changer for dermatologists, plastic surgeons and their patients," said Turn Bio CEO Anja Krammer. "The true breakthrough of combining our mRNA-based ERA therapy with our eTurna lipid delivery system, for the first time shows reversal from the effects of aging and offers an ability to improve the overall quality of the skin."

Turn Bio executives have committed to releasing additional data during a January webinar. Details will be announced in coming weeks.