By Matt Hale, International Sales & Marketing Director, HRS Heat Exchangers
Despite different legal and policy frameworks across the region, functional health and medicinal products containing CBD (cannabidiol) are growing in popularity across the Asia-Pacific region, with some sources suggesting the market could grow at 34.7% a year1. However traditional extraction processes do not always capitalise on the latest evaporation technology.
What is CBD?
CBD is a chemical extracted from hemp and marijuana plants, and while it an active ingredient in the cannabis drug, it does not cause the psychoactive effects associated with THC which is also found in the plants. Although medical studies are inconclusive, some of the claimed benefits of CBD include reducing inflammation, improving relaxation and focus, and slow down digestion. As such, it is often used to treat issues such as anxiety and insomnia, as well as some types of seizure and some digestive complaints.
Rotary evaporators have limited capacity and require a lot of time and attention (Source: HRS)
How is CBD extracted?
There are a number of different techniques for extracting the CBD from the hemp plant, although most of these require the use of solvents which are effective at separating the CBD from other chemical compounds found in the plant. Once the CBD has been extracted, the solvent is evaporated off leaving pure CBD oil.
Some methods use supercritical carbon dioxide in a closed-loop extractor to extract the CBD under pressure, resulting in a liquid mixture of CO2 and CBD, which must then be separated by evaporation, but a step involving alcohol solvents is usually still required. For this reason, the use of liquid solvents based on alcohols (ethanol, or isopropyl alcohol - IPA) or hydrocarbons (butane or propane) are also sometimes used and are much simpler and more straight forward. However, unless the evaporation step is carried out correctly, some alcohol residues may remain in the CBD oil mixture.
It is important to remember that even where CO2 extraction is used, a further stage involving alcohol solvents will still be required. Each method has its own benefits and drawbacks and the best method for one manufacturer may not be right for another.
Once the CBD oil has been separated from the solvent, then it is usually refined and distilled to produce pure CDB oil which is free from other compounds, such as THC, waxes and lipids. The exact nature of this refining process will impact on chemical profile of the resulting CBD product, and also depends on the extraction method used.
Considerations for evaporation
In order to maintain the characteristics of the CBD oil, low temperature evaporation techniques have to be used, often involving separate vacuum extraction systems to reduce the boiling point of the solvent.
At a small scale, laboratory-based rotary evaporation systems (with or without vacuum extraction) may be suitable – and indeed are one of the most common systems used today. But as the market grows and producers need to scale up production, they are likely to look to the type of low temperature evaporator used in pharmaceutical or food production. In addition, maximising solvent recovery with such a system requires a high level of vacuum control and so often requires skilled oversight of the process.
Multi-stage falling-film evaporation processes are highly efficient and allow much higher throughputs. As a continuous system it does not need to be disassembled and cleaned between each run and cleaning-in-place (CIP) is used to maintain hygienic condition and prevent contamination. Having different temperature regimes in each evaporation stage improves ethanol removal and the unit is highly efficient as each evaporation stage is held at a lower pressure than the previous one.
With 40 years of experience in providing heat exchangers and evaporators for the pharmaceutical and food sector, HRS provides equipment which meets the highest standards of hygiene and traceability and is well placed to help the rapidly growing CBD industry fulfil its market potential.
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