Algal culture improves cholesterol balance

HEALTH Enhancement Products, Inc. in conjunction with Wayne State University’s Department of Nutrition and Food Science in the College of Liberal Arts and Sciences, has published the results of its study on algal culture on cholesterol. The paper, “ProAlgaZyme sub-fraction improves the lipoprotein profile of hypercholesterolemic hamsters, while inhibiting production of betaine, carnitine, and choline metabolites” is found in the Journal of Nutrition & Metabolism.

The fractions and isolates derived from the proprietary algae culture “PAZ” (formerly referred to as “ProAlgaZyme”) were shown to be a viable candidate for supporting healthy cholesterol balance, in sharp contrast to the control group. The project, led by Smiti Gupta, Ph.D., associate professor of nutrition and food science at Wayne State University in Michigan, the United States, involved monitoring lipid metabolism in a widely accepted animal model for investigating human lipid metabolism. The scientific paper describes a follow-up study to the original research conducted by Dr Gupta. In the previous study, published in 2012, the test group consumed algal-infused water whilst simultaneously consuming a high fat diet. The algal fractions and isolates were shown to have a preventative beneficial effect against the negative effects of the high-fat diet on the animal’s plasma cholesterol levels. Specifically, the extracts increased high density lipoprotein cholesterol (HDL-C, aka “good” cholesterol), and reduced non-HDL cholesterol (“bad” cholesterol) and the ratio of total cholesterol/HDL-C, despite the ongoing consumption of high fat food.

The test subjects in the recent study consumed a high fat diet for four weeks, at which point they became hypercholesterolemic (i.e. they had high plasma cholesterol levels.). Subsequently, the animals were given the extracts for 0 (untreated), 3, 7, 10, 14, and 21 days whilst still on the high fat diet. The results indicated that the PAZ extracts may be a useful option for improving the plasma cholesterol profile despite the hypercholesterolemic state induced by a high fat diet.

Specifically, “bad” cholesterol concentrations significantly decreased in all subjects consuming the PAZ extracts, compared to those who were not treated. Furthermore, increased levels of “good” cholesterol could be seen as early as Day Three for that same group. By Day 21, “good” cholesterol levels increased by 28% and “bad” cholesterol levels decreased by 30%.

Metabolomics analysis was also conducted to analyse the concentration of certain metabolites (small molecules which are by-products of normal metabolic functions) in the blood. Administering the PAZ extract correlated with significantly decreased levels of several metabolites that are independent predictors of increased risk of atherosclerosis and cardiovascular disease.

Gene expression analysis was also conducted, to get a deeper insight into the increase in plasma HDL-c levels. Thus the expression levels (mRNA) of proteins involved in HDL-c metabolism were evaluated. By Day Ten, subjects showed a threefold increase in the gene expression of APO A1, a major protein associated with the production of HDL particles, the “good” cholesterol which increased sixfold by Day 21.

“To put this in perspective, the benefit of raising HDL can be explained by examining how these “good” cholesterol particles function: They play a key role in removing excess cholesterol from cell storage and transporting that cholesterol to the liver for excretion from the body,” said Amy Steffek, Ph.D., HEPI director of Research & Development. “They also have other propertiesMen Nike Air Huarache