Butter vs vegetable oils

SCIENTISTS at the UNC School of Medicine and the National Institutes of Health said they have found more evidence that questions the healthy practice of replacing butter and saturated fats with corn oil and other vegetable oils high in linoleic acid. It did reduce cholesterol level but not reduce the risk of heart attacks.

Their findings which were featured in the British Medical Journal in April imply that using vegetable oils high in linoleic acid might be worse than using butter when it comes to preventing heart disease. Such findings although requiring more research, were based on an analysis of previously unpublished data of a large controlled trial conducted in Minnesota (USA) nearly 50 years ago, as well as a broader analysis of published data from all similar trials of this dietary intervention.

The analyses show that interventions using linoleic acid-rich oils failed to reduce heart disease and overall mortality even though the intervention reduced cholesterol levels. In the Minnesota study, participants who had greater reduction in serum cholesterol had higher rather than lower risk of death.

“Altogether, this research leads us to conclude that incomplete publication of important data has contributed to the overestimation of benefits – and the underestimation of potential risks – of replacing saturated fat with vegetable oils rich in linoleic acid,” said co-first author Daisy Zamora, PhD, a researcher in the Department of Psychiatry at the UNC School of Medicine.

This healthy practice of replacing butter with other oils like corn oil or linoleic acid-rich oils including safflower oil, soybean oil, sunflower oil, and cottonseed oil, started in the 1960s. At the time, studies showed that using the oils would lower blood cholesterol levels. From there, some studies, including epidemiological and animal studies, have suggested that this intervention also reduces heart attack risk and related mortality. In 2009, the American Heart Association reaffirmed its view that a diet low in saturated fat and moderately high (5-10 percent of daily calories) amounts of linoleic acid and other omega-6 unsaturated fatty acids probably benefits the heart.

The Minnesota Coronary Experiment

However, randomized controlled trials – considered the gold standard for medical research – have never shown that linoleic acid-based dietary interventions reduce the risk of heart attacks or deaths.

The largest of these trials, the Minnesota Coronary Experiment (MCE), was conducted by researchers at the University of Minnesota between1968 and 1973. It enrolled 9,423 patients in six state mental hospitals and one state-run nursing home. Its results did not appear in a medical journal until 1989. The investigators reported then that a switch to corn oil from butter and other saturated fats did lower cholesterol levels but made no difference in terms of heart attacks, deaths due to heart attacks, or overall deaths.

In the course of investigating the health effects of linoleic acid-rich oils, the team of investigators led by Chris Ramsden, a medical investigator at the National Institutes of Health, came across the MCE study and the 1989 paper.

“Looking closely, we realized that some of the important analyses that the MCE investigators had planned to do were missing from the paper,” co-first author Ms Zamora said.

Robert Frantz, the son of the deceased MCE principal investigator, helped the team recover raw data from the study, which had been stored away for decades in files and on magnetic tapes. The team also found some trial data and analyses in a University of Minnesota master’s degree thesis written by written by Steven K. Broste, a student of one of the original investigators.

Using the recovered data to perform analyses that had been pre-specified by the MCE investigators but never published, the team confirmed the cholesterol-lowering effect of the dietary intervention. But they also found that in the recovered autopsy records, the corn oil group had almost twice the number of heart attacks as the control group.

Graphed summaries contained in Broste’s thesis indicated that in the intervention group, women and patients older than 65 experienced roughly 15 percent more deaths during the trial, compared to their control group counterparts.

“We did not recover the individual patient data underlying those graphs and so we couldn’t determine whether those differences were statistically significant,” said Ms Zamora.

She also cautioned that the other analyses were based on only partial recovery of patient data from the MCE files, so it would be premature to conclude from them that replacing saturated fats with corn oil is actually harmful to heart health.

In a much-cited study published in 2013, however, Ramsden, Zamora and colleagues were able to recover unpublished data from a smaller trial, the Sydney Diet Heart Study, and there they also found more cases of heart disease and death among patients who received a linoleic acid intervention (safflower oil), compared to controls.

Following their recovery of data from the MCE study, the researchers added new data to their existing datasets from the Sydney study and the other three published randomized clinical trials of linoleic acid-based dietary interventions. In a meta-analysis of the combined data, they again found no evidence that these interventions reduced deaths from heart disease or deaths from all causes.

“There were some differences among these studies, but on the whole they didn’t really disagree,” said Ms Zamora.

Subject to further study

Why linoleic acid-containing oils would lower cholesterol but worsen or at least fail to reduce heart attack risk is a subject of ongoing research and lively debate. Some studies suggest that these oils can – under certain circumstances – cause inflammation, a known risk factor for heart disease. There is also some evidence they can promote atherosclerosis when the oils are chemically modified in a process called oxidation.

The National Institutes of Health funded this research.

The study’s other first author, Christopher E. Ramsden, MD, is an adjunct assistant professor at UNC and a medical investigator in the section on nutritional neurosciences at the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The senior author is Joseph R. Hibbeln, MD, acting chief of NIAAA’s section on nutritional neurosciences. Other co-authors of the study include Sharon Majchrzak-Hong and Amit Ringel of NIH/NIAAA, John M. Davis and Chirayath M. Suchindran of UNC, Steven K. Broste of Medtronic Inc., and Robert P. Frantz of the Mayo Clinic in Minneapolis, Minnesota.