Faster, cheaper drug manufacturing with engineered catalysts

ORGANIC catalysts are essential for a number of industrial applications, such as drug manufacturing, but their inability to work within the same system or in water means that their efficiency is somewhat limited. Now Dutch scientists are a step closer to solving this problem by tweaking the polymer chains to allow the catalysts to work in water.

 

Researchers from the Eindhoven University of Technology did that by mimicking the structure of nature’s own catalysts – enzymes – and now these re-engineered catalysts could help to make drug manufacturing both faster and cheaper.

Enzymes have well-defined, compartmentalised three-dimensional structures mean that their active sites are very specific for their particular substrates, making enzyme catalysis extremely efficient. A crucial characteristic of enzymes is that their outsides are hydrophilic, allowing them to work in the watery environment of the body, while the insides – where the active site is situated – are hydrophobic.
Catalysts, on the other hand, are typically much smaller molecules that do not have large three-dimensional structures around them, and thus tend to be much less selective. However, it is often the case that these catalysts can stimulate reactions that enzymes cannot.

Best of both worlds
Dr Anja Palmans of the Eindhoven University of Technology thinks there is a way to get the best of both worlds.

“We can mimic the three-dimensional structure of an enzyme using polymer chains,” says Dr. Palmans. “Using what is known as a supramolecular recognition unit, we can fold these chains into compartmentalised architectures much similar to enzymes, which we can then insert a catalytic core into. The folded polymer chain will have a hydrophilic outer surface similar to an enzyme, allowing the synthetic catalyst to work in water.”
The possibilities opened up by this research are numerous. Enzyme-like activity in a completely synthetic system could be used for reaction cascades in which multiple reactions are occurring at once in the same environment. “When making drugs, for example, the current process involves carrying out one reaction, isolating the product and then purifying the product before moving on to the next reaction and repeating the whole process,” she says.

Standard organic catalysts tend to inhibit or alter each other’s activity and so cannot be used within the same system, but with these synthetic catalysts the active site is shielded and so they do not interfere with each other. “This allows one to have a system in which a number of reactions can be happening simultaneously within a single procedure,” Dr. Palmans explains.
The Eindhoven University of Technology has been the base of this research, providing a unique multidisciplinary environment that has been fundamental to the success of the work, according to Dr. Palmans. “The institute we work in, the Institute for Complex Molecular Systems, was specifically created so that researchers from a number of different disciplines can work within the same building,” she says. “We have polymer chemists to work with the polymer chains, organic chemists to develop the catalysts and supramolecular recognition units, polymer physicists to aid our understanding of the folding and to bring complex methods of analysis, as well as mathematicians who utilise their knowledge of modelling.”

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The first experiments on cascade catalytic systems are now running, but the next step will be to relate the structure of the polymers back to the catalytic activity. “We can now shield the catalysts within the polymer; that has been proven,” says Palmans, “but what we really want to do now is to get back to design principals so that we can improve the levels of catalysis. The mathematicians we are working with will be crucial for this step, as their knowledge of models will allow us to work on molecular design.”
It will be another few years before the final results of this intriguing research are published, and it could be that it helps to revolutionise the use of organic catalysts. ADIDAS