Heart attack risk increase associated with total hip,<br> knee replacement procedures

Source：Archives of Internal Medicine Release Date：2012-07-30 304

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CHICAGO – Total knee replacement (TKR) and total hip replacement (THR) surgeries were associated with increased risk of acute myocardial infarction (AMI, heart attack) in the first two weeks following surgical procedures, according to a report published by Archives of Internal Medicine, a JAMA Network publication.

“This study demonstrated an increased risk of AMI during the first two weeks after THR (25-fold) and TKR (31-fold) surgery compared with matched controls. The risk of AMI sharply decreased after this period, although it remained significantly elevated in the first six weeks for THR patients. The association was strongest in patients 80 years or older, whereas we could not detect a significantly increased risk in patients younger than 60 years,” said Arief Lalmohamed, Pharm. D., of Utrecht University, the Netherlands, and colleagues.

“Furthermore, a previous AMI in the six months before surgery increased the risk of new AMI during the first six weeks after THR and TKR (4-fold increase) surgery but did not modify the relationship between THR or TKR and AMI,” the authors conclude.Air Huarache Classic