New benchmark for optical microscopy

BRUKER (NASDAQ: BRKR) has released the BioScope Resolve™ during the Sixth AFM BioMed Conference.

The biological atomic force microscope (bioAFM) uses the company’s proprietary PeakForce Tapping technology. Besides supporting the highest imaging resolution, it enables researchers to achieve piconewton level force measurements on biological samples.

Bruker's BioScope Resolve enables breakthrough imaging and mechanical property mapping of the biological details of cells, tissues, and biomolecular structures (Photo: Business Wire)

According to professor Dr. Daniel Muller of the Department of Biosystems Science and Engineering at the ETH Zürich, Switzerland, with PeakForce Tapping his lab was able to achieve in a very time-efficient and controlled manner the force control and resolution needed to produce innovative ligand-receptor interaction map employing functionalized probes on live cells.

Further, the BioScope Resolve enables the breakthrough imaging and mechanical property mapping of the biological details of cells, tissues, and biomolecular structures, which has never been observed with a bioAFM on an inverted optical microscope (IOM) before. It can also provide real-time atomic force microscopy and optical microscopy data set correlation. This can be used to obtain unique insights into life sciences research.

According to Dr. Lewis Francis of the College of Medicine and Center of NanoHealth at Swansea University, United Kingdom, this is the first time that a bioAFM analysis can directly correlate high-resolution molecular structures with function on the same cell.

“BioScope Resolve provides the dynamic range and resolution necessary to allow a deeper understanding of structure-function relationships at cell and tissue surfaces,” Dr. Francis added.

Bruker AFM business executive vice president and general manager David V. Rossi said the BioScope Resolve establishes a new benchmark for high-resolution imaging and cell mechanics characterization capabilities that are fully integrated with optical microscopy. “It builds upon our exclusive and leading PeakForce Tapping technology to enable the highest performance bioAFM that researchers of every experience level will find very easy to use,” Mr. Rossi further stated.